seemed to help us a lot was alternating a relaxing place with a big city. Paris and then Annecy. Lake Lugano then Venice then Capri then Rome. Alitalia may suck - but it was super cheap flying Venice to Naples. BTW, Lake Lugano is another extremely stunning place - on the Italian Swiss border - for some reason it is a semi-tropical pocket amid the mountains and snow. Tidbit: George Harrison loved it so much he had his ashes sprinkled there.
What's good too is that the wine - even the house - is so fantastic - that you never feel sluggish
Wish I could afford first class next time. We had tons of frequent flyer miles and booked it last time. Leave JFK at 5, filet mignon and wine at 7, sleep (at least everyone else) in Charles De Gaulle by 9 next morning.
My bucket list - Have you been to any?
Sicily
Cinque Terre
Lake Maggiorre
Loire Valley wine tour - in caves
Bicycle tour somewhere - nothing too strenuous - but met someone who loved it.
Kracow - touring concentration camps is supposed to change your life forever more.
Sound of Music setting Salzburg
I am really driven by French and Italian food though - or I would include Spain too.