a product sold by many supplement companies called 5-Loxin inhibits the inflammatory enzyme, 5-lipoxygenase. I had used Curcumin for a number of years for a bad knee and found it helped.. When 5-Loxin became available I started using it (I buy mine from Life Extension Foundation). I found it really added to the effect of Curcumin and noticed a significant reduction of swelling of the knee.
I highly recommend it to those suffering with arthritis or anybody with swelling, pain and attendant reduced range of motion in joints.
here's some research on 5-Loxin from PubMed: A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin®for treatment of osteoarthritis of the knee
CONCLUSION: 5-Loxin reduces pain and improves physical functioning significantly in OA patients; and it is safe for human consumption. 5-Loxin may exert its beneficial effects by controlling inflammatory responses through reducing proinflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage in OA patients.
... and:
Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect? 5-Loxin is a compound extracted from an ancient herb that might be considered as a potent lipooxygenase inhibitor. The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound. Moreover, in this trial, a statistically significant decrease in matrix metalloproteinase enzyme serum level suggests that, in addition to the observed symptomatic effect, such a compound might have a disease modifying effect in osteoarthritis. Further studies are required both to confirm the symptomatic efficacy and acceptable safety profile and to evaluate the potential chondromodulating effect of this compound.
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