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when your gut bacteria is killed off by anti-biotic or illness.
An example you might know of...when you take anti-biotics you usually get diarrhea.
All the "yeasty beasties" in your gut are being killed along with whatever bug the anti-biotic was targeting.
Taking probiotics helps prevent that.
And, research is showing there are many different kinds of good beasties.
I usually take probiotcs in a capsule, which has several kinds of the good guys.
Yogurt "with live cultures" usually only has 1-2 types of probiotics.
Worth your time to read up on the subject, fascinating info. 
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