The CDC has reported a significant rise in the number of children dying from influenza, including dangerous and rare variations of the virus.

There were 280 child flu deaths in the U.S. last year, the highest number aside from 2009-10, during the H1N1 pandemic. The rates of children being vaccinated against influenza have also fallen.

Influenza-associated encephalopathy (IAE) is a rare, severe neurologic complication of influenza. It can lead to varying degrees of brain dysfunction. The new report says that 84 percent of children with IAE whose vaccination status was known were not vaccinated.