AI Helps Unravel a Cause of Alzheimer's Disease and Identify a Therapeutic Candidate [View all]

April 25, 2025

A new study found that a gene recently recognized as a biomarker for Alzheimer’s disease is actually a cause of it, due to its previously unknown secondary function. Researchers at the University of California San Diego used artificial intelligence to help both unravel this mystery of Alzheimer’s disease and discover a potential treatment that obstructs the gene’s moonlighting role.

The research team published their results on April 23 in the journal Cell.

About one in nine people aged 65 and older has Alzheimer’s disease, the most common cause of dementia. While some particular genes, when mutated, can lead to Alzheimer’s, that connection only accounts for a small percentage of all Alzheimer’s patients. The vast majority of patients do not have a mutation in a known disease-causing gene; instead, they have “spontaneous” Alzheimer’s, and the causes for that are unclear.

Discovering those causes could ultimately improve medical care.

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https://today.ucsd.edu/story/ai-helps-unravel-a-cause-of-alzheimers-disease-and-identify-a-therapeutic-candidate