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highplainsdem

(59,234 posts)
Sat Nov 22, 2025, 03:07 PM Nov 22

Young People Are Tripping on Benadryl--and It's Always a Bad Time (Wired, November 17)

Alarming story.

https://www.wired.com/story/young-people-are-tripping-on-benadryl-and-its-always-a-bad-time/

-snip-

When used in high doses, diphenhydramine, an ingredient in Benadryl, functions as a deliriant, a hallucinogenic class of drugs, which appear to be becoming increasingly popular among young people for nonmedical purposes. Unlike psychedelics or other hallucinogens, there’s no real potential for a good trip on a deliriant. According to the people I spoke to, every trip is bad, every trip is brutal, and that’s the point.

In 2020, the “Benadryl challenge” gained traction on TikTok, daring participants to take doses of at least 12 Benadryl pills for an intense trip. The trend, which resurfaces every few years, drew attention to the psychoactive effects of deliriants. “I saw a video about it on TikTok once, so I knew it could be used recreationally,” one user tells me.

With little to no harm reduction information readily available about high levels of consumption, problems began to rise. In May 2020, three Texas teens were treated for Benadryl overdoses in just a week, one of whom was just 14 years old and took 14 pills. The 14-year-old recovered and returned home the next day. In August 2020, a 15-year-old died from a seizure after overdosing on the drug in Oklahoma. In September 2020, the FDA issued a warning for parents to hide and lock up their Benadryl supply, warning of the potential risk of heart problems, seizures, and, less commonly, comas and even death. Despite the warning, the trend seems to have persisted. In 2020, there were 4,618 cases reported to US Poison Centers for Benadryl usage; that number climbed to 5,960 in 2023, according to a study published in Pediatrics Open Science in August. Benadryl and deliriants in general have embedded themselves as staples on the fringes of the American youth—a cheap and easy way to get fucked up. WIRED reached out to Benadryl manufacturer Kenvue for comment. A spokesperson for the company stated, “This behavior is extremely concerning and dangerous,” and encouraged consumers to “carefully read and follow the instructions on the label and contact their health care professional should they have questions.”

-snip-

The users I spoke to described a range of unpleasant symptoms including a dramatic increase in heart rate, nausea, breathlessness, dry mouth, and severe memory loss. That’s just if the trip goes “well.” But the fun doesn’t stop there. Ryan Marino, a toxicologist and assistant professor at Case Western Reserve University’s School of Medicine, says, “Use of these central anticholinergics does cause amnesia (and impair memory formation) and so may certainly make people feel like they are developing dementia or having cognitive issues.” John felt his neurocognitive function decaying firsthand, having had to drop his college chemistry class when he was taking Benadryl.

-snip-


Much more at the link.

I'd never heard of this before. And if any drug-taking DUers think even for a second that this might be an interesting trip, you'd better reread the next-to-last paragraph quoted above.

I'm posting this for any DUers who might have noticed friends or family suddenly taking Benadryl when they'd never seemed to have allergies.
49 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Young People Are Tripping on Benadryl--and It's Always a Bad Time (Wired, November 17) (Original Post) highplainsdem Nov 22 OP
Now I know why the drug store ask for my ID and ask for my birthday........... Lovie777 Nov 22 #1
Some people take it to help them sleep. chowder66 Nov 22 #2
I take a Benadryl now and then for nasal allergy. ananda Nov 22 #7
I hear it can make people drowsy so they use it for sleep. I've never heard of anyone using it chowder66 Nov 22 #15
That's how I use it. Just one every so often. ananda Nov 22 #18
I have a reaction to Benadryl so I don't use it. chowder66 Nov 22 #19
I think it's interesting that a drug... ananda Nov 22 #22
yes because you dont take 12 of them like these idiots.nt. drray23 Nov 22 #26
No I'm sorry to say it can have some really bad side effects : mucifer Nov 22 #27
Now JustAnotherGen Nov 22 #3
are magic mushrooms that difficult to procure? DBoon Nov 22 #4
If you take the time to learn, you can grow a years worth in one batch Lochloosa Nov 22 #34
If you are interested in the neurobiology... mr715 Nov 22 #5
If the trip is unpleasant, why do it? RandomNumbers Nov 22 #6
If you read the full article, it explains. highplainsdem Nov 22 #8
it is paywalled for me, sadly RandomNumbers Nov 22 #11
I'd like to read it too canetoad Nov 22 #16
Thanks for posting the archive link Alice Kramden Nov 22 #37
Interesting question. Have you ever heard of anyone enjoying their first cigarette? 3catwoman3 Nov 22 #25
I can socially smoke mr715 Nov 22 #29
I've never even tried one, nor even held an unlighted one. My mom smoked... 3catwoman3 Nov 22 #32
Oral route marijuana produces wildly different experiences from smoking. mr715 Nov 22 #33
I smoked pot for over 30 years and can't stand edibles. Lochloosa Nov 22 #35
So I've heard. I've made it to 74 without ever partaking... 3catwoman3 Nov 22 #36
I smoked 1/8 of a Marlboro I_UndergroundPanther Nov 23 #45
I only found it mildly irritating the first time. RandomNumbers Nov 23 #49
A self-harm technique for numbing the emotions Alice Kramden Nov 22 #38
ChubbyEmu is always a win Sympthsical Nov 22 #9
robitussun and nutmeg bring about delirium too purr-rat beauty Nov 22 #10
I tried nutmeg canetoad Nov 22 #17
Gawd almighty, Karma13612 Nov 22 #12
Sometimes I take Hydroxyzine too mvd Nov 22 #14
Hydroxyzine palmoate I think is a formulation for anxiety mr715 Nov 22 #30
Sadly, Karma13612 Nov 23 #41
Sorry to hear that mvd Nov 23 #44
Same thing happens Karma13612 Nov 23 #48
I'm with you BlueSpot Nov 22 #40
I was taking it occasionally for allergies. My pulmonologist told me to stop. She said Liberal In Texas Nov 22 #13
IDK if they applies to the next gen antihistamines like Claritin or Zyrtec or Xyzal (which is the gold standard) nt mr715 Nov 22 #31
She said take Zyrtec instead. So I am. Liberal In Texas Nov 23 #47
anticholinergic drugs increase the risk of dementia Mosby Nov 22 #20
Oops made the same comment you did. Deleting now. I need every brain cell I can keep no Benadryl for me. mucifer Nov 22 #28
Just smoke a little POT, for christ sake! Jack Valentino Nov 22 #21
I get paranoid on pot. Karma13612 Nov 23 #42
Is there Anything young idiots aren't taking to get high? MerryBlooms Nov 22 #23
I buy benadryl to barely survive with 5 indoor cats MerryBlooms Nov 22 #24
Just do normal drugs, kids. BannonsLiver Nov 22 #39
In junior high back in the 60's Karma13612 Nov 23 #43
Oh, a TikTok challenge. Summon the idiots!!!! flvegan Nov 23 #46

Lovie777

(21,320 posts)
1. Now I know why the drug store ask for my ID and ask for my birthday...........
Sat Nov 22, 2025, 03:28 PM
Nov 22

I ask him why he needed the information because I have been taking them for 20 years because of my sinuses.

He told me they can be used as hallucinogen drugs by young people.

ananda

(34,156 posts)
7. I take a Benadryl now and then for nasal allergy.
Sat Nov 22, 2025, 05:45 PM
Nov 22

It works. And it has no side effect whatsoever.

chowder66

(11,665 posts)
15. I hear it can make people drowsy so they use it for sleep. I've never heard of anyone using it
Sat Nov 22, 2025, 07:22 PM
Nov 22

regularly, just more like in a pinch when they need it.

ananda

(34,156 posts)
18. That's how I use it. Just one every so often.
Sat Nov 22, 2025, 07:42 PM
Nov 22

Since it works, I don't use it very often.

chowder66

(11,665 posts)
19. I have a reaction to Benadryl so I don't use it.
Sat Nov 22, 2025, 07:58 PM
Nov 22

I get jittery and hyper from Benadryl, Sudafed and Nyqil so I avoid it like the plague.

ananda

(34,156 posts)
22. I think it's interesting that a drug...
Sat Nov 22, 2025, 08:30 PM
Nov 22

could have such different effects on different
people.

Ti's possible that Benadryl might work for
me as a placebo effect because I expect it to.

mucifer

(25,463 posts)
27. No I'm sorry to say it can have some really bad side effects :
Sat Nov 22, 2025, 10:37 PM
Nov 22

It increases your risk of Dementia see Mosby's post below.

Lochloosa

(16,643 posts)
34. If you take the time to learn, you can grow a years worth in one batch
Sat Nov 22, 2025, 10:56 PM
Nov 22

Lot's of good videos online. The spores are legal to buy. They don't contain any psilocybin, so their perfectly legal to possess.

Once you get the hang of it, it's fairly straight forward to grow them and the added bonus is you know where they came from.

mr715

(2,476 posts)
5. If you are interested in the neurobiology...
Sat Nov 22, 2025, 04:29 PM
Nov 22

Benedryl at super high doses produces delirium, which is distinguished from psychedelic hallucination because they do not arise from the serotonin system, but rather the acetylcholine system. They are supposed to be intensely unpleasant - with oddly consistently imagery. People tend to experience elongated body shapes, shadows, and articulated joints like in insects.

I find benedryl unpleasant at low doses, but I have taken excessive Nyquil (Doxylamine, different drug similar effect) that has given me a really unpleasant fugue dream state.

Overuse of anticholinergic antihistamines like benedryl is also under evaluation for increased risk of dementia and neurodegeneration.

RandomNumbers

(19,024 posts)
6. If the trip is unpleasant, why do it?
Sat Nov 22, 2025, 05:43 PM
Nov 22

That's something I never understood about addicts, or "recreational" users who do stuff and then admit it wasn't fun.

Decades ago I did my share of risky behavior, including a dab of this or that; but I can't remember ever consuming something that I didn't believe would be pleasant. (Mostly I stuck to pot; there were a couple "one time" experiences with other stuff but there was always something wrong and the high didn't seem worth it.)

3catwoman3

(28,344 posts)
25. Interesting question. Have you ever heard of anyone enjoying their first cigarette?
Sat Nov 22, 2025, 10:19 PM
Nov 22

Coughing, gagging, choking, and even vomiting seem to be pretty universal experiences, yet people go back for more. Why?

mr715

(2,476 posts)
29. I can socially smoke
Sat Nov 22, 2025, 10:44 PM
Nov 22

Whenever I do, I feel ill. But I want to smoke more. It is the most bizarre sensation.

3catwoman3

(28,344 posts)
32. I've never even tried one, nor even held an unlighted one. My mom smoked...
Sat Nov 22, 2025, 10:52 PM
Nov 22

...when I was little (eventually quit) and I find the smell utterly disgusting.

If I were ever to try marijuana, it would have to be in a funny brownie, as I couldn't possibly smoke it.

mr715

(2,476 posts)
33. Oral route marijuana produces wildly different experiences from smoking.
Sat Nov 22, 2025, 10:55 PM
Nov 22

I've seen some poor friends curl into a fetal position because of how edibles work. It is near impossible to get too much weed by smoking, but edibles you can get dosages that are uncomfortably high without knowing it.

Especially when the edibles taste good.

Lochloosa

(16,643 posts)
35. I smoked pot for over 30 years and can't stand edibles.
Sat Nov 22, 2025, 11:00 PM
Nov 22

It is a totally different high and in my case, hard to regulate.

Haven't smoked in 20+ years, so I tried them a couple of times. Not for me.

3catwoman3

(28,344 posts)
36. So I've heard. I've made it to 74 without ever partaking...
Sat Nov 22, 2025, 11:04 PM
Nov 22

...and altho I'm curious, and it's legal in Illinois, it still feels vaguely criminal to me, so I'll likely never experience it.

I_UndergroundPanther

(13,323 posts)
45. I smoked 1/8 of a Marlboro
Sun Nov 23, 2025, 01:49 AM
Nov 23

I was on a psych unit in the early 80’s back then they had rooms set aside for smokers. Since all the interesting people were in there I was in there too sometimes.

What was the big deal about cigarettes? I wondered because everyone in my family smoked but me and everyone in the unit was asking for them giving them out for a buck.

I was curious to try it. I asked 3 people offered I had the choice of some brand I didn’t know, a Newport or a Marlboro. I picked the Marlboro. They found it amusing I held it like a joint.

First puff it tasted horrendous. Second puff it made my throat hurt and my lungs itch deep inside .By the 3rd puff I had enough. This sucked ass.

I wanted to get out of the room and go lie down I was quickly becoming miserable. As I walked to my room I got something similar to tunnel vision. It was unnerving.

I laid down and the nausea hit. Drooling I was scared I was gonna puke and the dizziness and weird vision didn’t help me feel confident I would make it to the toilet.

However being emetiphobic I know just how to breathe a certain way to control nausea .I laid there closed my eyes breathed and waited until it was over.

That was my one and only time a cigarette touched my lips.

RandomNumbers

(19,024 posts)
49. I only found it mildly irritating the first time.
Sun Nov 23, 2025, 11:55 AM
Nov 23

The social benefits outweighed any discomfort. But the discomfort was objectively mild, compared to what is described in this article.

After 6 months of regular cigarette smoking, I no longer found the benefits outweighing the costs. It took me 2+ years to break free of the habit that had already formed. That was an important life lesson - but not one I would recommend anyone undertake on purpose.

Alice Kramden

(2,852 posts)
38. A self-harm technique for numbing the emotions
Sat Nov 22, 2025, 11:36 PM
Nov 22

Excerpt:

This escape is sometimes reached with brutal numbness, a complete dulling of the mind. Tom, a 27-year-old user from Europe, explains that once the novelty of the terrifying visuals wears off, users can become used to them, and then they feel nothing. “If someone is depressed and they do psychedelics, their feelings will become more intense, whereas deliriants do the opposite,” says Tom, who didn’t want to use his real name for professional reasons. “They numb all the emotions.”

purr-rat beauty

(889 posts)
10. robitussun and nutmeg bring about delirium too
Sat Nov 22, 2025, 05:50 PM
Nov 22

They we're interesting....the nutmeg being quite hard hitting surprisingly

One n' done experiment....I do not recommend

canetoad

(19,934 posts)
17. I tried nutmeg
Sat Nov 22, 2025, 07:34 PM
Nov 22

Fifty years ago and I agree. Not particularly pleasant, wouldn't do it again.

Karma13612

(4,897 posts)
12. Gawd almighty,
Sat Nov 22, 2025, 05:53 PM
Nov 22

please don’t restrict Benadryl.

I use it for occasional bouts of allergies and insomnia, I take one before vaccines to help reduce the local swelling in the injection area, and always when traveling staying in hotels that are dog-friendly.

I remember when a popular decongestant was moved behind the counter when people started using it to make methamphetamine IIRC.

So sick of things getting harder because some people act like idiots.

mvd

(65,813 posts)
14. Sometimes I take Hydroxyzine too
Sat Nov 22, 2025, 06:07 PM
Nov 22

It is also an antihistamine and used more for anxiety. Both have their uses when used properly.

mr715

(2,476 posts)
30. Hydroxyzine palmoate I think is a formulation for anxiety
Sat Nov 22, 2025, 10:46 PM
Nov 22

It is primarily an antihistamine in the same family as benedryl and doxylamine. It produces the same sorta weird fuzzy drowsiness than is different from other sleep meds. I've always found it unpleasant, and it shuts me down for the whole next day.

But if I have allergies and anxiety, hey, it works.

Karma13612

(4,897 posts)
41. Sadly,
Sun Nov 23, 2025, 01:29 AM
Nov 23

I become incredibly dizzy on hydroxyzine.

I was prescribed it for anxiety and definitely worked in reverse as I was totally dizzy to the point of severe anxiety!

mvd

(65,813 posts)
44. Sorry to hear that
Sun Nov 23, 2025, 01:44 AM
Nov 23

It makes me a little drowsy/sleepy but not dizzy. I take a small dosage. Can’t imagine using these meds to get a high.

BlueSpot

(1,229 posts)
40. I'm with you
Sat Nov 22, 2025, 11:57 PM
Nov 22

Benadryl is my go-to for allergies. I know some people have side effects but this is the only allergy pill I've tried that doesn't have any for me. I recently had work done in my home that created lots of dust. Just a few Benadryls over a couple of days got me through that. A couple of Benadryls and and aspirin cure a sinus headache in just half an hour. If they take this away, I'm going to be in a world of hurt even though I only take them now and then.

Liberal In Texas

(15,867 posts)
13. I was taking it occasionally for allergies. My pulmonologist told me to stop. She said
Sat Nov 22, 2025, 06:02 PM
Nov 22

there is evidence that it can lead to Alzheimer's and dementia. I said fine with me, I don't need anything that might make me stupider.

I haven't looked this up on the great internet, it's just what my doctor said.

mr715

(2,476 posts)
31. IDK if they applies to the next gen antihistamines like Claritin or Zyrtec or Xyzal (which is the gold standard) nt
Sat Nov 22, 2025, 10:47 PM
Nov 22

mucifer

(25,463 posts)
28. Oops made the same comment you did. Deleting now. I need every brain cell I can keep no Benadryl for me.
Sat Nov 22, 2025, 10:39 PM
Nov 22

Karma13612

(4,897 posts)
42. I get paranoid on pot.
Sun Nov 23, 2025, 01:32 AM
Nov 23

Too bad because I have anxiety and there isn’t much I can use that doesn’t cause me nasty side effects.

MerryBlooms

(12,124 posts)
23. Is there Anything young idiots aren't taking to get high?
Sat Nov 22, 2025, 08:39 PM
Nov 22

For F's sake, spray paint is locked up! So sick a this shit.
Question is, why these kids looking to escape reality and getting high with everything they can get their hands on?!?
Shit, just give em some lead paint chips, those already illegal

MerryBlooms

(12,124 posts)
24. I buy benadryl to barely survive with 5 indoor cats
Sat Nov 22, 2025, 08:50 PM
Nov 22

Was kinda fine before the 2 rescues. Now, because I can't resist snuggling or kick them out my bed, yep, 2 benadryl around 5:30am and 2 about 9pm.
Doc put me on Claritin, pff,no good
At least the benadryl works a little. Still have watering eyes, itching ears, etc... but the snuggling is totally worth it
I used to take sudafed, it worked better, but pharmacy actcls like you're trying to get an opioid. Driver's license, signature... lol I just want less snot, watering eyes and itching ears

Karma13612

(4,897 posts)
43. In junior high back in the 60's
Sun Nov 23, 2025, 01:40 AM
Nov 23

I was friends with the principal’s daughter.

She decided it would be fun to hyperventilate as a way to get a high.

Nope, not my cup of tea.

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